Intravenous dexmedetomidine, but not midazolam, prolongs bupivacaine spinal anesthesia

Intravenous dexmedetomidine prolongs bupivacaine spinal analgesia.

BACKGROUND The prolongation of spinal anesthesia by using clonidine through the oral, intravenous and spinal route has been known. The new alpha 2 agonist, dexmedetomidine has been proved to prolong the spinal anesthesia through the intrathecal route. We hypothesized that dexmedetomidine when administered intravenously following spinal block, also prolongs spinal analgesia. METHODS 48 patient...

Effect of Intravenous Dexmedetomidine on the Action of Spinal Bupivacaine in Comparision with Intravenous Midazolam Authors

1 Associate Professor, 2* Assistant Professor, 3 Post Graduate, 4 Professor: Department of Anesthesiology, Gandhi Medical College, Padmarao Nagar, Secunderabad, Telangana *Corresponding Author Dr .D. Suresh Chander Associate Professor, Dept of Anesthesiology, Gandhi Medical College, Padmarao Nagar, Secunderabad, Email: [email protected] ABSTRACT Background: The present study was desig...

Midazolam in Spinal Anesthesia — Intrathecal or Intravenous?

Comparison of Intravenous Dexmedetomidine and Midazolam for Bispectral Index-Guided Sedation During Spinal Anesthesia

BACKGROUND Despite the high frequency of hypotension during spinal anesthesia with proper sedation, no previous report has compared the hemodynamic effects of dexmedetomidine and midazolam sedation during spinal anesthesia. We compared the effects of bispectral index (BIS)-guided intravenous sedation using midazolam or dexmedetomidine on hemodynamics and recovery profiles in patients who underw...

Low-dose Bupivacaine with Dexmedetomidine Prevents Hypotension After Spinal Anesthesia

Background: We assessed whether intrathecal low-dose bupivacaine with dexmedetomidine could reduce the incidence of spinal anesthesia (SA)-related hypotension. Methods: In total, 47 patients undergoing urological or orthopedic surgery under SA were randomized into two groups. SA was induced using 12.5 mg of hyperbaric bupivacaine alone (Group B; n = 24 patients) or 6 mg of hyperbaric bupivacain...